![]() ![]() If the INR falls significantly below the therapeutic range additional anticoagulant therapy should be considered for patients with a high risk of thrombosis. This protocol gives relatively aggressive reversal of warfarin. Patient with an INR above the therapeutic range with a high risk of bleedingĦ-12 hours early testing may be necessary if INR excessively above 9 or risk of bleeding assessed as very high. May offer advantage over FFP as a small volume and there is no time delay in thawing. The INR can be measured within 15mins of dose completion and doses repeated as necessary depending on the INR. ![]() WarfarinĢ5-50 IU/kg Octaplex plus 2 units of FFP if Octaplex not readily available 4 units FFP.Īssess patient continuously until both INR 5.0 use a dose closer to 50IU/kg.Īdminister at a rate of 3ml/min or as tolerated by the patient. It is for any clinically significant bleeding where warfarin induced coagulopathy is considered a contributing factor. This intervention is designed to rapidly reverse the INR in what may be life-threatening circumstances. Patient has clinically significant bleeding There is a smart phone app available to assist with managing over dose. If a patient has a high INR consider the following possible causesĪn elevated INR can significantly increase the risk of death from haemorrhage Smart Phone app You may report side effects to FDA at 1-80.Treatment strategy for warfarin over-anticoagulation ![]() Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur.
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